Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl

Formulation, release characteristics, and bioavailability study of gastroretentive floating matrix tablet and floating raft system of Mebeverine HCl

To prolong the residence time of dosage forms within the gastrointestinal tract until all drug is released at the desired rate is one of the real challenges for oral controlled-release drug delivery systems. This study was designed to develop a controlled-release floating matrix tablet and floating raft system of Mebeverine HCl (MbH) and evaluate different excipients for their floating behavior...

Formulation and Evaluation of Floating Matrix Tablet of Atenolol For

The purpose of this research was to develop gastro-retentive delivery system of atenolol which, after oral administration should have the ability to prolong gastric residence time with desired in vitro release profile. Atenolol was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by direct compression technique, using natural ...

Formulation of Gastroretentive floating microparticles for Ofloxacin

In the present study an attempt was made to prepare alginate floating microparticles by ionotropic gelation method with calcium carbonate (CaCO3) 1% w/v in gelation medium used as gas-forming agent for oral delivery of Ofloxacin. Chitosan was used to enhance the drug encapsulation efficiency. Various physiochemical properties such as particle size, shape, in vitro buoyancy and drug release was ...

بررسی تاثیر نوع و میزان پلیمرهای هیدروفیل بر میزان رهش و خصوصیات شناوری قرص های ماتریکسی پروپرانولول هیدروکلراید

Background and purpose: The gastroretentive drug delivery systems can be retained in the stomach due to low bulk density. This assist in improving the oral sustained delivery of drugs that have an absorption window in a particular region of the gastrointestinal tract. These systems release the drug content before reaching the absorption site and provide optimal bioavailability. Several approach...

formulation and in vitro evaluation of ketoprofen gastric floating tablet